Wiley Series on Pharmaceutical Science and Biotechnology Practices, Applications and Methods: Oral Bioavailability Assessment : Basics and Strategies for Drug Discovery and Development by Ayman F. El-Kattan download ebook TXT, PDF
9781118916698 1118916697 Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in drug discovery and development. Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development Explains how preclinical animal models used in preclinical testing and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development, This book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. Specifically geared to personnel in the pharmaceutical and biotechnology industries, the book emphasizes the impact of drug transporters and their impact on drug absorption and practices for addressing bioavailability problems. The author includes tutorials for applying these strategies to medicinal chemistry for hit selection, lead optimization, and development candidate selection. The author routinely gives a short course on the topic and presents the material in an accessible and practical manner that can help readers reduce failure rate in drug development when moving a candidate drug from the bench to the clinic.
9781118916698 1118916697 Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in drug discovery and development. Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development Explains how preclinical animal models used in preclinical testing and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development, This book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development. Specifically geared to personnel in the pharmaceutical and biotechnology industries, the book emphasizes the impact of drug transporters and their impact on drug absorption and practices for addressing bioavailability problems. The author includes tutorials for applying these strategies to medicinal chemistry for hit selection, lead optimization, and development candidate selection. The author routinely gives a short course on the topic and presents the material in an accessible and practical manner that can help readers reduce failure rate in drug development when moving a candidate drug from the bench to the clinic.