Leonard K. Kaczmarek - Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels EPUB, MOBI, TXT
9780471930136 English 047193013X New Promising Tools for Drug Development and Discovery Researchers, New Promising Tools for Drug Development and Discovery Researchers This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies. Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels is divided into three logical sections: Section One: Neuronal Voltage-Gated Ion Channel Functions Section Two: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function Section Three: Drug Discovery Targets and Technology Among the key topics addressed are: Biochemical and molecular mechanisms and pathways in neuronal voltage-gated ion channel regulation Physiological bases of targeting ion channels in disease Advances in screening technologies, and methods for regulating neuronal voltage-gated ion channels Custom-developed technologies for ion channel drug discovery Utility of neuronal voltage-gated ion channel targets for the development of new medicines in traditional and emerging therapeutic areas Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study. Book jacket. Leonard K. Kaczmarek, PhD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist. Book jacket., This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
9780471930136 English 047193013X New Promising Tools for Drug Development and Discovery Researchers, New Promising Tools for Drug Development and Discovery Researchers This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies. Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels is divided into three logical sections: Section One: Neuronal Voltage-Gated Ion Channel Functions Section Two: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function Section Three: Drug Discovery Targets and Technology Among the key topics addressed are: Biochemical and molecular mechanisms and pathways in neuronal voltage-gated ion channel regulation Physiological bases of targeting ion channels in disease Advances in screening technologies, and methods for regulating neuronal voltage-gated ion channels Custom-developed technologies for ion channel drug discovery Utility of neuronal voltage-gated ion channel targets for the development of new medicines in traditional and emerging therapeutic areas Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study. Book jacket. Leonard K. Kaczmarek, PhD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist. Book jacket., This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.